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Gadolinium oxide nanocrystal-based autofluorescent composite nanoparticles as T1-weighted contrast agents for early diagnosis of cancer
Shen ZY(沈折玉)
2013-10-25
Conference Name2013 World Congress on Engineering and Technology
Source Publication2013 World Congress on Engineering and Technology
Pages9—9
Conference Date2013-10-25
Conference Place三亚
Publication Place三亚
AbstractEarly diagnosis of cancer greatly increases the chances of a radical resection. The sensitivity of magnetic resonance imaging (MRI) techniques for detecting early tumor can be increased with the assistance of a positive MRI contrast agent. However, the traditional positive MRI contrast agents, such as Gd-chelates and Gd-based inorganic nanoparticles, are often limited by the cytotoxicity and low specificity. Here, we propose a new design of MRI contrast agent based on gadolinium oxide nanocrystals (GON) for targeted imaging and cancer early diagnosis with good biocompatibility. The GON was prepared using a polyol method and then encapsulated into albumin nanoparticles (AN), which are cross-linked with glutaraldehyde and found to exhibit bright and stable autofluorescence without conjugation to any fluorescent agent. After that, the targeted molecule folic acid (FA) was conjugated onto the surface of GON-loaded AN (GON-AN) to construct GON-AN-FA composite. As-prepared nanoparticles are biocompatible and well stable in serum. The results of MRI relaxation studies show that the longitudinal relaxivity (r1) of GON-AN (11.6 mM-1 s-1) and GON-AN-FA (10.8 mM-1 s-1) is much larger than that of traditional positive MRI contrast agents, such as Magnevist (4.7 mM-1 s-1). The results of cell viability assays indicate that GON-AN and GON-AN-FA are almost non-cytotoxic. Furthermore, the specificity of GON-AN and GON-AN-FA were evaluated with two kinds of cancer cells which overexpress folate receptor alpha (FRα). The results reinforce that the autofluorescent GON-AN-FA is targetable to cancer cells via recognition of ligand FA and receptor FRα. Therefore, our autofluorescent GON-AN-FA possessing large longitudinal relaxivity and good biocompatibility represents a significant advance for the targeted imaging and early diagnosis of cancer.
description.department功能材料与纳米器件事业部
Indexed By其他国内刊物
Document Type会议论文
Identifierhttp://ir.nimte.ac.cn/handle/174433/10259
Collection宁波所知识产出
Corresponding AuthorShen ZY(沈折玉)
Recommended Citation
GB/T 7714
Shen ZY. Gadolinium oxide nanocrystal-based autofluorescent composite nanoparticles as T1-weighted contrast agents for early diagnosis of cancer[C]. 三亚,2013:9—9.
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李雨桐
2013-12-22 10:30
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