NIMTE OpenIR  > 2017专题
Neuropeptide Y Y-1 receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging
Li, Juan; Tian, Yuchen; Shan, Dingying; Gong, An; Zeng, Leyong; Ren, Wenzhi; Xiang, Lingchao; Gerhard, Ethan; Zhao, Jinshun; Yang, Jian; Wu, Aiguo
2017
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume116Pages:106-117
AbstractTargeted molecular imaging has attracted great attention in cancer diagnosis and treatment. However, most clinically used ultrasound contrast agents (UCAs) are non-targeted microbubbles seldom used for cancer imaging. Here, we fabricated fluorescent nanobubbles (NBs) by encapsulation of liquid tetrade-cafluorohexane (C6F14) within biodegradable photoluminescent polymers (BPLPs) through an emulsion evaporation process and conjugation of PNBL-NPY ligand for specific targeting of Y-1 receptors overexpressed in breast tumors. The developed PNBL-NPY modified NBs were uniform in size with good dispersibility and photostability, presenting good ultrasound enhancement. Further, in vitro and in vivo results indicated that the fabricated NBs exhibit high affinity and specificity to Y-1 receptor-overexpressing breast cancer cells and tumors with minimal toxicity and damage to organs. Our developed PNBL-NPY-modified NBs are novel targeted UCAs for safe, efficient and specific targeted breast cancer imaging, and may provide a new nanoplatform for early cancer diagnosis and treatment in the future. (C) 2016 Elsevier Ltd. All rights reserved.
Document Type期刊论文
Identifierhttp://ir.nimte.ac.cn/handle/174433/14006
Collection2017专题
Recommended Citation
GB/T 7714
Li, Juan,Tian, Yuchen,Shan, Dingying,et al. Neuropeptide Y Y-1 receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging[J]. BIOMATERIALS,2017,116:106-117.
APA Li, Juan.,Tian, Yuchen.,Shan, Dingying.,Gong, An.,Zeng, Leyong.,...&Wu, Aiguo.(2017).Neuropeptide Y Y-1 receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging.BIOMATERIALS,116,106-117.
MLA Li, Juan,et al."Neuropeptide Y Y-1 receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging".BIOMATERIALS 116(2017):106-117.
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