NIMTE OpenIR  > 2018专题
Enhanced hemocompatibility of flat and hollow fiber membranes via a heparin free surface crosslinking strategy
Wang, Hui; Li, Jinglong; Liu, Fu; Li, Tiantian; Zhong, Yun; Lin, Haibo; He, Jidong
2018
Source PublicationREACTIVE & FUNCTIONAL POLYMERS
Volume124Pages:104-114
AbstractInsufficient hemocompatibility is challenging for current dialysis membranes. The current modification methods have some limitations in effectiveness, practicality and cost. Herein, we develop a heparin-free crosslinking approach to enhance the hemocompatibility of both the flat (polylactide) and hollow fiber (polysulfone) membranes with heparin -mimicking surface. Poly (triethoxyvinylsilane-N-vinyl-2-pyrrolidone) (P (VTES-VP)) is first introduced to the membrane surface to improve the hydrophilicity, which is facilitated to the adsorption and further crosslinking of poly (triethoxyvinylsilane-Acrylic acid -Sodium 4-vinylbenzenssulfonate) (P(VTESAA-SSNa)). The mixture of N, N-dimethylacetamide (DMAc) and water was modulated for good solubility, swelling and adsorption of precopolymer. The chemical structure of the heparin -mimicking membrane was confirmed by attenuated total reflectance Fourier transform infrared spectra (FTIR-ATR), X-ray photoelectron spectroscopy (XPS), weight measurement and scanning electron microscopy (SEM). The hydrophilicity was improved by the heparin -mimicking surface. Moreover, the heparin -mimicking membranes presents higher platelet resistance, prolonged coagulation time (APTT for similar to 180.1 s), decreased Plasma fibrinogen (FIB for similar to 122 mg/dL), and suppressed complement activation. More importantly, the heparin -free crosslinking approach can be utilized to significantly enhance the hemocompatibility of commercial PSF hollow fiber membranes, indicating its potential application in heparin free dialyzers.
KeywordPolyethersulfone Membranes Polylactide Membrane Blood Compatibility Antifouling Properties Polysulfone Membranes Anticoagulant Coatings Polymers Pyrrolidone) Biomaterials
Subject AreaChemistry ; Engineering ; Polymer Science
Language英语
Document Type期刊论文
Identifierhttp://ir.nimte.ac.cn/handle/174433/16770
Collection2018专题
Recommended Citation
GB/T 7714
Wang, Hui,Li, Jinglong,Liu, Fu,et al. Enhanced hemocompatibility of flat and hollow fiber membranes via a heparin free surface crosslinking strategy[J]. REACTIVE & FUNCTIONAL POLYMERS,2018,124:104-114.
APA Wang, Hui.,Li, Jinglong.,Liu, Fu.,Li, Tiantian.,Zhong, Yun.,...&He, Jidong.(2018).Enhanced hemocompatibility of flat and hollow fiber membranes via a heparin free surface crosslinking strategy.REACTIVE & FUNCTIONAL POLYMERS,124,104-114.
MLA Wang, Hui,et al."Enhanced hemocompatibility of flat and hollow fiber membranes via a heparin free surface crosslinking strategy".REACTIVE & FUNCTIONAL POLYMERS 124(2018):104-114.
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