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Designing pH-Responsive Biodegradable Polymer Coatings for Controlled Drug Release via Vapor-Based Route
Shi, Xiao; Ye, Yumin; Wang, Hui; Liu, Fu; Wang, Zhijie
2018
发表期刊ACS APPLIED MATERIALS & INTERFACES
卷号10期号:44页码:38449-38458
摘要We present the design of a novel pH-responsive drug release system that is achieved by solventless encapsulation of drugs within a microporous membrane using a thin capping layer of biodegradable poly(methacrylic anhydride) (PMAH) coating. The coating was synthesized via a mild vapor polymerization process, namely, initiated chemical vapor deposition, which allowed perfect retention of the anhydride groups during deposition. The synthesized polyanhydride underwent degradation upon exposure to aqueous buffers, resulting in soluble poly(methacrylic acid). The degradation behavior of PMAH is highly pH-dependent, and the degradation rate under pH 10 is 15 times faster than that under pH 1. The release profile of a model drug rifampicin clearly exhibited two stages: the initial stage when the coatings were being degraded but the drugs were well stored and the second stage when drugs were gradually exposed to the medium and released. The drug release also showed strong pH responsiveness where the duration of the initial stage under pH 1 was more than 7 and 3 times longer than that under pH 10 and 7.4, respectively, and the release rates at pH 7.4 and 10 were significantly faster than that at pH 1. The pH-dependent degradation of the encapsulant thus enabled good preservation of drugs under low pH environment but high drug release efficiency under neutral and alkaline environment, suggesting potential applications in site-specific drug delivery systems.
关键词Atmospheric Plasma Process In-vitro Degradation Methacrylic Anhydride Triggered Release Delivery System Porous Silicon Fabrication Deposition Surfaces Hydrolysis
学科领域Science & Technology - Other Topics ; Materials Science
语种英语
文献类型期刊论文
条目标识符http://ir.nimte.ac.cn/handle/174433/17037
专题2018专题
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GB/T 7714
Shi, Xiao,Ye, Yumin,Wang, Hui,et al. Designing pH-Responsive Biodegradable Polymer Coatings for Controlled Drug Release via Vapor-Based Route[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(44):38449-38458.
APA Shi, Xiao,Ye, Yumin,Wang, Hui,Liu, Fu,&Wang, Zhijie.(2018).Designing pH-Responsive Biodegradable Polymer Coatings for Controlled Drug Release via Vapor-Based Route.ACS APPLIED MATERIALS & INTERFACES,10(44),38449-38458.
MLA Shi, Xiao,et al."Designing pH-Responsive Biodegradable Polymer Coatings for Controlled Drug Release via Vapor-Based Route".ACS APPLIED MATERIALS & INTERFACES 10.44(2018):38449-38458.
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