NIMTE OpenIR  > 2018专题
Y-1-receptor-ligand-functionalized ultrasmall upconversion nanoparticles for tumor-targeted trimodality imaging and photodynamic therapy with low toxicity
Yu, Zhangsen; Xia, Yuanzhi; Xing, Jie; Li, Zihou; Zhen, Jianjun; Jin, Yinhua; Tian, Yuchen; Liu, Chuang; Jiang, Zhenqi; Li, Juan; Wu, Aiguo
2018
Source PublicationNANOSCALE
Volume10Issue:36Pages:17038-17052
AbstractAchieving efficient photodynamic therapy (PDT) in deeper biological tissue is still the biggest bottleneck that limits its widespread application in clinic. Although deeper biological tissue PDT could be realized through a combination of upconversion nanoparticles with a photosensitizer, issues with particle-size-induced upconversion fluorescence (UF) reduction and the related in vivo toxicity still cannot be solved properly. In this study, we synthesized Y1Rs-ligand [Pro(30), Nle(31), Bpa(32), Leu(34)] NPY(28-36) (NPY)-modified and photosensitizer MC540-loaded LiLuF4: Yb, Er@nLiGdF(4)@mSiO(2) multifunctional nanocomposites (MNPs) with a core-multishell structure and ultrasmall size. Their in vitro and in vivo breast tumor targeting, trimodality imaging performance, PDT therapeutic efficacy, and acute toxicity were evaluated. Our results demonstrated that the core-multishell MNPs(MC540) could achieve excellent UF imaging, and that doping with Gd3+ and Lu3+ rare earth ions could enhance the MR and CT imaging performance. In addition, the mSiO(2) shell provided a higher loading rate for the photosensitizer MC540, and the DSPE-PEG thin layer coating outside the MNPs(MC540) further improved the water solubility and biocompatibility, reducing the acute toxicity of the nanocomposites. Finally, the NPY modification enhanced the targetability of MNPs(MC540)/DSPE-PEG-NPY to breast tumors, improving the trimodality UF, CT, and MR imaging performance and PDT efficacy for Y-1-receptor-overexpressed breast cancer. In general, our developed multifunctional nanocomposites can serve as a theranostic agent with low toxicity, providing great potential for their use in clinical breast cancer diagnosis and therapy.
KeywordNear-infrared-light Cancer Statistics Contrast Agents 808 Nm Core Luminescence Nanocrystals Drug Nanoplatform Receptors
Subject AreaPhysics
Language英语
Document Type期刊论文
Identifierhttp://ir.nimte.ac.cn/handle/174433/17185
Collection2018专题
Recommended Citation
GB/T 7714
Yu, Zhangsen,Xia, Yuanzhi,Xing, Jie,et al. Y-1-receptor-ligand-functionalized ultrasmall upconversion nanoparticles for tumor-targeted trimodality imaging and photodynamic therapy with low toxicity[J]. NANOSCALE,2018,10(36):17038-17052.
APA Yu, Zhangsen.,Xia, Yuanzhi.,Xing, Jie.,Li, Zihou.,Zhen, Jianjun.,...&Wu, Aiguo.(2018).Y-1-receptor-ligand-functionalized ultrasmall upconversion nanoparticles for tumor-targeted trimodality imaging and photodynamic therapy with low toxicity.NANOSCALE,10(36),17038-17052.
MLA Yu, Zhangsen,et al."Y-1-receptor-ligand-functionalized ultrasmall upconversion nanoparticles for tumor-targeted trimodality imaging and photodynamic therapy with low toxicity".NANOSCALE 10.36(2018):17038-17052.
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