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In Vitro Cytotoxicity and Morphological Assessments of GO-ZnO against the MCF-7 Cells: Determination of Singlet Oxygen by Chemical Trapping
Shaheen, Fozia; Aziz, Muhammad Hammad; Fatima, Mahvish; Khan, Muhammad Ajmal; Ahmed, Faisal; Ahmad, Riaz; Ahmad, Muhammad Ashfaq; Alkhuraiji, Turki S.; Akram, Muhammad Waseem; Raza, Rizwan; Ali, Syed Mansoor
2018
发表期刊NANOMATERIALS
卷号8期号:7
摘要Graphene-based materials have attracted considerable interest owing to their distinctive characteristics, such as their biocompatibility in terms of both their physical and intrinsic chemical properties. The use of nanomaterials with graphene as a biocompatible agent has increased due to an uptick in dedication from biomedical investigators. Here, GO-ZnO was characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), ultraviolet-visible (UV-Vis) spectroscopy, energy dispersive X-ray analysis (EDAX), and Raman spectroscopy for structural, morphological, and elemental analysis. The toxic extent of GO-ZnO was noted by a methyl-thiazole-tetrazolium (MTT), while cellular morphology was observed towards the MCF-7 cells using an inverted microscope at magnification 40 x. The cytotoxic effect of GO-ZnO investigated the cell viability reduction in a dose-dependent manner, as well as prompted the cell demise /destruction in an apoptotic way. Moreover, statistical analysis was performed on the experimental outcomes, with p-values < 0.05 kept as significant to elucidate the results. The generation of reactive oxygen species (ROS) demonstrated the potential applicability of graphene in tumor treatment. These key results attest to the efficacy of GO-ZnO nanocomposites as a substantial candidate for breast malignancy treatment.
关键词Reduced Graphene Oxide Photothermal Therapy Oxidative Stress Antibacterial Properties Breast-cancer Nanocomposites Toxicity Biocompatibility Nanomaterials Delivery
学科领域Science & Technology - Other Topics ; Materials Science
语种英语
文献类型期刊论文
条目标识符http://ir.nimte.ac.cn/handle/174433/17330
专题2018专题
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GB/T 7714
Shaheen, Fozia,Aziz, Muhammad Hammad,Fatima, Mahvish,et al. In Vitro Cytotoxicity and Morphological Assessments of GO-ZnO against the MCF-7 Cells: Determination of Singlet Oxygen by Chemical Trapping[J]. NANOMATERIALS,2018,8(7).
APA Shaheen, Fozia.,Aziz, Muhammad Hammad.,Fatima, Mahvish.,Khan, Muhammad Ajmal.,Ahmed, Faisal.,...&Ali, Syed Mansoor.(2018).In Vitro Cytotoxicity and Morphological Assessments of GO-ZnO against the MCF-7 Cells: Determination of Singlet Oxygen by Chemical Trapping.NANOMATERIALS,8(7).
MLA Shaheen, Fozia,et al."In Vitro Cytotoxicity and Morphological Assessments of GO-ZnO against the MCF-7 Cells: Determination of Singlet Oxygen by Chemical Trapping".NANOMATERIALS 8.7(2018).
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