NIMTE OpenIR  > 2018专题
Controllable synthesis of Fe3O4 nanoflowers: enhanced imaging guided cancer therapy and comparison of photothermal efficiency with black-TiO2
Saeed, Madiha; Iqbal, M. Zubair; Ren, Wenzhi; Xia, Yuanzhi; Liu, Chuang; Khan, Waheed S.; Wu, Aiguo
2018
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
Volume6Issue:22Pages:3800-3810
AbstractPhotothermal therapy (PTT) has emerged as one of the promising cancer therapy approaches. However, nanoparticles (NPs) which are used for PTT might be biopersistent and potentially toxic. The current research explores the promising use of Fe3O4 nanoflowers as nontoxic, efficient photothermal, and strong T-2 type magnetic resonance imaging (MRI) contrast agents for imaging-guided photothermal cancer therapy. In this study, a facile solvothermal method is used to fabricate PEG-coated Fe3O4 nanoflowers with controllable dimensions. Their successful fabrication, the effect of the reaction parameters, and their magnetic properties are investigated in depth. The therapeutic performance of the Fe3O4 nanoflowers (Fe-NFs) is evaluated and compared with commercially available black TiO2 nanoparticles (b-TiO2) under an 808 nm laser. The photothermal therapy efficiency of the Fe-NFs is observed to be better than that of the reported Fe3O4 nanoparticles. In vitro and in vivo investigation demonstrates that the therapeutic performance of the Fe-NFs is comparable to that of b-TiO2. Moreover, the Fe-NFs show excellent magnetic properties and magnetic resonance imaging capability to monitor therapeutic performance.
KeywordIron-oxide Nanoparticles Magnetic Nanoparticles Inorganic Nanoparticles Biomedical Applications Tumor Ablation In-vivo Hyperthermia Nanocrystals Toxicity Nanomaterials
Subject AreaChemistry
Language英语
Document Type期刊论文
Identifierhttp://ir.nimte.ac.cn/handle/174433/17397
Collection2018专题
Recommended Citation
GB/T 7714
Saeed, Madiha,Iqbal, M. Zubair,Ren, Wenzhi,et al. Controllable synthesis of Fe3O4 nanoflowers: enhanced imaging guided cancer therapy and comparison of photothermal efficiency with black-TiO2[J]. JOURNAL OF MATERIALS CHEMISTRY B,2018,6(22):3800-3810.
APA Saeed, Madiha.,Iqbal, M. Zubair.,Ren, Wenzhi.,Xia, Yuanzhi.,Liu, Chuang.,...&Wu, Aiguo.(2018).Controllable synthesis of Fe3O4 nanoflowers: enhanced imaging guided cancer therapy and comparison of photothermal efficiency with black-TiO2.JOURNAL OF MATERIALS CHEMISTRY B,6(22),3800-3810.
MLA Saeed, Madiha,et al."Controllable synthesis of Fe3O4 nanoflowers: enhanced imaging guided cancer therapy and comparison of photothermal efficiency with black-TiO2".JOURNAL OF MATERIALS CHEMISTRY B 6.22(2018):3800-3810.
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